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Several of the plant extracts that showed interaction
2019-07-19
Several of the plant extracts that showed interaction with ERα and ERβ have differing reports concerning estrogenicity and receptor binding. Extracts of dong quai stimulated MCF-7 proliferation but failed to increase uterine weight or transactivate either ERα or ERβ in a cell assay (Amato et al., 20
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OxLDL down regulates eNOS and
2019-07-19
OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial SMIP004 [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNOS-mediated IRE1α
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br Materials and methods br Results and discussion br
2019-07-19
Materials and methods Results and discussion Conclusion The glycyl endopeptidase from papaya latex was partitioned using aqueous two-phase (10%PEG 6000–10% (NH4)2SO4) in combination with ammonium sulphate precipitation (40–60% saturation). The partially purified glycyl endopeptidase showed
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br Material and methods br Results br
2019-07-19
Material and methods Results Discussion Isolated hsp90 inhibitors have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore,
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The development of C S mutation has been
2019-07-19
The development of C797S mutation has been reported in vivo in a small cohort (15 subjects) of EGFR T790M positive patients progressing after Osimertinib: this tertiary mutation was found, using a droplet digital PCR (ddPCR) assay, in 40% of patients after AR to this agent, while 33% of the cases ex
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Through an unknown mechanism RING
2019-07-19
Through an unknown mechanism, RING/Ubox-type E3 dimers and the N-terminal tail have been shown to function as a modulator of full E3 ubiquitin ligase activity [27]. LRSAM1 promotes a significant enhancement in the formation of the high-molecular-weight products or E3 activity when the RING domain is
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The structure of the HOIP RBR LDD module bound
2019-07-19
The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi
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The acids applied in this
2019-07-19
The acids applied in this study are commonly used in dental practice. Phosphoric KN-92 phosphate is an oxyacid used regularly for adhesion of resin composites. Enamel phosphoric acid etching can dissolve and demineralize the inorganic [Ca10(PO4)6(OH)2] matrix, creating micro pores and microgrooves
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Introduction Nucleic acids are polyanionic and their negativ
2019-07-19
Introduction Nucleic acids are polyanionic and their negatively charged nucleotides allow the binding of cationic dyes, such as acridine orange (3,6-dimethylaminoacridine). Acridine orange (AO) was first synthesized in 1889, but its ability to bind nucleic acids was only reported in 1940, with grea
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Naphthoquine phosphate chemical br Discussion Electroporatio
2019-07-19
Discussion Electroporation is a convenient and efficient way to introduce foreign material into Naphthoquine phosphate chemical [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant
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Since free testosterone diffuses into
2019-07-19
Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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Considering the protumoral functions of TAMs new therapies a
2019-07-19
Considering the protumoral functions of TAMs, new therapies against TAMs have recently gained interest. Such treatments, particularly inhibitors of the colony stimulating factor 1 receptor (CSF-1R), are currently evaluated in several clinical trials [19]. CSF-1R inhibitors may also be of interest in
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br Significance Dysregulation of dopamine homeostasis
2019-07-18
Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of hdac inhibitors governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitaliz
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Reports on the participation of NDH along with other
2019-07-18
Reports on the participation of NDH2 along with other respiratory complexes in the formation of a large supercomplex (Grandier-Vazeille et al. 2001) or even a respirosome-like structure in S. cerevisiae mitochondria (Matus-Ortega et al. 2015) are very intriguing. Similarly, in Y. lypolytica mitochon
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In a recent study Tomkins et al analyzed
2019-07-18
In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for