Unexpectedly we found no association of TVmets nor

Unexpectedly, we found no association of TVmets nor of the ratio TVmets-TVprimary with CN status, suggesting that neither metastatic volume nor its ratio to TVprimary was a factor in the decision for or against CN. This is contrary to our assumption that intermediate-risk patients with low metastatic volume would have been offered CN more often than patients with high metastatic volume or small primary tumour. However, the decision to remove the primary tumour substracted the substantial volume from the baseline TV. In the Cox regression analysis, only CN status was therefore significantly associated with survival in patients with intermediate-risk synchronous mRCC, who were treated with sunitinib. This is in line with previous trials in the cytokine era where the benefit of CN was proven [15,16]. However, taking the other parameters that were part of the regression analysis and which were each individually associated with a survival benefit into account (TBactual, IMDC 2 vs. 3 factors, and TVactual ) it is likely that CN status summarizes a favorable prognostic subgroup rather than being proof of a beneficial effect of debulking nephrectomy in the era of targeted therapy. Presently, only retrospective data are available that suggest that appropriately selected patients with mRCC benefit from Cyanine3.5 alkyne Supplier of CN with systemic targeted therapy [6,17–19]. Therefore, the results of the ongoing randomized controlled CARMENA trial that compares CN followed by sunitinib to sunitinib alone would have to be awaited to definitely settle this question.

Conclusion

Introduction
Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for about 80% to 90% of renal parenchymal neoplasms. Approximately 30% of patients have distant metastases at the time of diagnosis, and of those patients with RCC who undergo surgical resection, 20% to 40% have distant metastases. Once metastases occur, the 5-year survival rate of patients is only 0% to 20%. RCC is resistant to traditional chemotherapy drugs, and the response rate with immunotherapy regimens is only 5% to 20% [1]. Currently, tyrosine kinase inhibitors (TKIs) that target vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors, such as sunitinib, sorafenib, and pazopanib, are the first-line options for the treatment of metastatic RCC (mRCC). In a study comparing the efficacy of sunitinib and interferon-α in treatment-naive patients with mRCC, the median overall survival (mOS) of patients who received sunitinib treatment was significantly longer than that of patients who received immunotherapy (26.4 vs. 21.8mo, respectively; P = 0.051) [2]. Another study of immunotherapy in patients with mRCC reported lower median survival times of 17.5 and 13 months, respectively, with high-dose intravenous interleukin-2 and subcutaneous interleukin-2 plus interferon-α [3].
A widely used prognostic model of mRCC is the Memorial Sloan-Kettering Cancer Center (MSKCC) model [4], which includes 5 principal adverse prognostic factors, Karnofsky score<80, serum lactate dehydrogenase (LDH) concentration>1.5×the upper limit of normal (ULN), low hemoglobin (<13g/l for males;<11.5g/l for females), serum calcium concentration>10mg/dl, and diagnosis to treatment time of<1 year. Based on these factors, patients can be segregated into 3 risk categories, favorable (no prognostic factors), intermediate (1 or 2 prognostic factors), and poor (3–5 prognostic factors). In the study of Motzer et al. [4], in which 463 patients with mRCC were treated with interferon-α, mOS times in the 3 prognostic groups were 28.6, 14.6, and 4.5 months, respectively. In another study in which 353 previously untreated patients with mRCC were evaluated on the basis of the MSKCC model, Mekhail et al. [5] concluded that prior radiotherapy and>1 metastatic site were also prognostic factors.
It should be noted that the MSKCC prognostic model was initially based on clinical trials of immunotherapeutic agents, but recently, a few retrospective studies have shown that the MSKCC prognostic model can also apply to mRCC treated with TKIs [6,7]. There is a need to explore additional prognostic factors for mRCCs treated with TKIs, and the role of the MSKCC prognostic model in East Asian, especially Chinese, populations still needs to be further confirmed. Thus, we retrospectively reviewed the data from 5 clinical trials of first-line TKI therapy in Chinese patients with mRCC.

Urban trees present a feasible form of urban

Urban trees present a feasible form of urban green infrastructures for heat mitigation. The shading effect of urban trees reduces the net energy cisapride thus modifying the urban energy balance (Roy et al., 2012) and cooling the urban canopy and boundary layers by reducing the sensible heat (Armson et al., 2012; Rahman et al., 2015). The participatory role of urban trees with its shading effects and evapotranspiration in urban land-atmosphere interactions also assists in improving the building energy efficiency by declining cooling demand (Akbari et al., 2001). The houses with shade trees have shown decrease in peak cooling demand of over 30% in previous studies (Akbari et al., 1997). Similarly, shade trees also contribute to human thermal comfort by reducing surface and air temperatures and reducing direct and diffusive shortwave (solar) radiation from reaching canyon facets (Hedquist and Brazel, 2014; de Abreu-Harbicha et al., 2015).
The effects of shading and evapotranspiration of trees on the built environment have triggered various research efforts to incorporate trees in urban modeling systems. Lee and Park (2008) included trees in the vegetated urban canopy model (VUCM) by including the hydrological processes of trees via evapotranspiration (ET), but without taking into account the effect of radiative shading. Krayenhoff et al. (2014) included the radiative effects of tall trees in multi-layer urban canopy model (UCM) based on Monte Carlo ray-tracing method. Wang (2014) integrated urban trees into a single-layer UCM, enabling heat exchange between trees and urban facets via modifications of the radiative view factors. This modified view factors was later adopted by (Ryu et al., 2016), together with other biophysical processes of urban trees such as ET. Song and Wang (2015a, 2015b) integrated urban trees into a single column atmospheric model, and used it to investigate the impact of urban trees on urban boundary-layer dynamics. These studies using offline (stand-alone) UCMs have shown that the inclusion of trees has significant impacts on predicting the overall cooling effect by urban green infrastructures for the local environment at the suburban (neighborhood to city) scales (Song and Wang, 2016; Wang et al., 2016). However, these studies are offline in the sense that the urban land surface processes with trees included are not fully interactive with the driving environmental forcings, resulting in potential errors in quantifying the actual effect of trees in an integrated land-atmosphere system.
For online platforms with fully coupled land-atmospheric dynamic modules, such as the Weather Research and Forecasting (WRF) model, the incorporation of the shading effect of urban trees not only allows an enhanced accuracy in predicting regional climate, but also has significant implications to sustainable urban planning in, e.g. building energy efficiency (Akbari et al., 1997, 2001). Among the developed urban modeling systems, the single-layer UCM (Kusaka et al., 2001; Masson, 2000) integrated into the WRF platform (Chen et al., 2011) has undergone continuous improvements and been widely used (Wang et al., 2013; Yang et al., 2015a) for accounting the land-atmosphere feedback and predicting urban hydroclimate. Nevertheless, modeling of water and energy budgets related to urban trees remains largely inadequate and presents as an open challenge hitherto in WRF-UCMs (Krayenhoff et al., 2014, 2015; Ryu et al., 2016). Numerical difficulty still persists in resolving the participatory role of trees in the exchange of radiative energy in built terrains (viz. shading by blockage of direct solar radiation, and trapping of terrestrial radiation) (Krayenhoff et al., 2014; Wang, 2014).
The purpose of the present study is to incorporate urban trees to be participatory into the fully coupled WRF-UCM system, by including the shading/trapping effect (Fig. 1) in radiative heat exchange in street canyons. This study applied the Monte Carlo method for radiative exchange in 2D street canyons, integrating urban trees and their shading effect derived by a previous study (Wang, 2014). With the integrated model, fully coupled regional scale simulations were carried out for the Phoenix Metropolitan area.

Anti-diabetic Compound Library Only a few red squirrel studies have been conducted within

Only a few red squirrel studies have been conducted within urban areas despite the fact that the species is currently quite common in urban habitats in Europe (Luniak, 2004; Babińska-Werka and Żółw, 2008). One local study conducted in Brussels indicated that patch size and patch quality have positive effects and that isolation has a negative effect on red squirrel patch occurrence in urban areas (Verbylen et al., 2003). A study in Warsaw parks also indicated that park size positively affects red squirrel abundance (Babinska-Werka and Zolow, 2008). However, large-scale studies with multiple study sites and covering different habitats are needed to better understand the urbanization process of red squirrel. In addition, as squirrels are important dispersal agents of seeds (Steele, 2008), they may also impact on distribution of urban trees. Therefore, it is important to know how urbanization influence squirrel abundance.
The main aim of this study was to analyze how human density affects the winter abundance of red squirrels throughout Finland. The analysis included also habitat type, natural (size of the Norway spruce cone crop) or artificial (number of feeding sites) food abundance, and natural (northern goshawk, Accipiter gentilis, L.) or human-associated (feral cats, Felis domesticus, L.) predator abundance. In addition, we also studied whether latitude and the time of the winter season affect the squirrel abundance. We conducted our study during the winter season because winter is a critical period for the survival of squirrels in the northern latitudes (Selonen et al., 2015), and because due to the lack of Anti-diabetic Compound Library in the broad-leaved trees, the detectability of squirrels is high during winter (Hernández, 2014). We predicted that if squirrels somehow benefit from humans, then their abundance should increase with human density and should be higher within urban than other habitat types. If food resources, either artificial or natural, have an effect then squirrel abundance should increase with the number of feeding sites or with the size of the Norway spruce cone crop. If squirrel winter abundance is dependent on predators, then their abundance should change with predator abundance. Because the severity of winter increases toward the north, we predicted that red squirrel abundance would decrease from the south to the north. Due to winter mortality, we predicted that squirrel abundance would decrease during the winter. However, the squirrel abundance could also increase towards to the spring, because the visibility of squirrels increases due their early-starting mating season.

Methods

Results
Altogether, 1781 squirrels were observed along the transect routes across all seasons (early winter 785, mid-winter 448, late winter 548). The number of observed squirrel abundance, feeding sites, goshawks and cats in the different habitats are shown in Table 1. In general, the relative squirrel abundance was lower in forest (1.43 individuals/10km transect route) than in rural (4.00 individuals/10km transect route) or urban (4.24 individuals/10km transect route) habitats. In addition, the number of feeding sites per 10km transect route was lower in forest (0.72) than in rural (19.46) or urban (18.26) habitats. The relative abundance of northern goshawks in urban areas (0.57 individuals/10km transect route) was approximately twice as high as in forest (0.27) or rural (0.22) habitats. Approximately twice the number of feral cats was observed in rural (0.66 individuals/10km transect route) than in urban habitats (0.30), whereas only one cat was observed in the forest habitats (Table 1).
In the transect route analyses, the zero-inflated negative binomial models were top-ranked in the first model selection step (results not shown). In the second step of the transect route-specific analysis, the top-ranked model included the length of the transect route, latitude, longitude, season, abundance of feral cats, quadratic effect of human density and abundance of feeding places and their interaction. The other model within 2 ΔAIC of the best model included these same variables, but also interaction between quadratic human density and latitude (Table 2). However, since this interaction was not significant this variable can be considered as uninformative parameter (sensu Arnold, 2010) and only the top ranked model was investigated later on. The number of squirrels increased with the increasing length of a transect route, quadratic effect of human density (Fig. 1a) and abundance of feeding sites (Fig. 1b) and decreased with increasing latitude (Table 3). The significant negative interaction between quadratic human population and abundance of feeding sites suggest that feeding increased squirrel numbers more in areas where there was lower human densities (Table 3). There was also tendency that abundance of feral cats decreased squirrel numbers (Table 3). The relative squirrel abundance was significantly lower during the mid-winter and late winter counts than the early winter counts. The abundances of goshawks was not significantly associated with squirrel numbers (Table 2).

Laminin 925-933 cost The power spectrum of an unweighted LFM chirp is approximately

The power spectrum of an unweighted LFM chirp is approximately rectangular and yields a sinc-like function after pulse compression. The compressed chirp signal contains a peak side lobe level (PSL) at approximately −13 dB. This higher value of PSL will mask out the main lobe width (MLW) from the weak scatterer and will potentially degrade the image contrast by appearing as false echoes. Therefore, the higher values of the PSL are unacceptable in modern medical ultrasound imaging systems operating at a dynamic range of more than 60 dB (Johnston and Fairhead 1986; Misaridis and Jensen 2005b).
To reduce the higher PSL of the compressed chirp signal, a strong weighting function is applied either on the transmitting signal or on the received matched filter; the latter case is termed a mismatched filter. Windowing on the excitation signal causes a reduction in the transmitting energy and Hence. penetration depth, whereas windowing on the matched filter results in reduced gain in the SNR and axial resolution. Therefore, a trade-off between the MLW and PSL exists in the pulse Laminin 925-933 cost process of the LFM signal (Adams 1991; Milleit 1970).
Non-linear frequency-modulated (NLFM) chirp signals provide an alternative means to modify the rectangular power spectrum of the LFM chirp into a desirable shape. The NLFM chirp can be designed to optimize the signal transmitting energy and the shape of the power spectrum so that it matches spectrally the transfer function of the transducer. This results in transmission of more energy though the transducer, which potentially improves the SNR and penetration depth. Also, a reduced PSL will be obtained after pulse compression without using any additional windowing function on the matched filter (Arif et al. 2010b; Gran and Jensen 2007; Harput et al. 2013; Pollakowski and Ermert 1994).
The effects of shaping the transmitting spectrum using the NLFM chirp for improved spectral matching with the transmitter were first studied by Brandon (1973). He designed the non-linear pulse compression system for radar to obtain high resolution with reduced loss in the SNR. The NLFM chirp was designed using the least-squares optimization method for synthetic transmit aperture B-mode imaging (Gran and Jensen 2007). The NLFM signal with the quadratic instantaneous frequency function was designed and implemented for tissue harmonic imaging (Song et al. 2011).

Theory and Signal Design

Proposed Methods
Two methods were proposed to illustrate the scenarios of non-overlap and overlap harmonic conditions. The proposed system flowcharts are provided in Figure 3.

Simulation and Experimental Investigation

Results

Discussion and Conclusions
In this study, non-linear and linear frequency modulation could use long signals because a single element probe was employed in the experiments. Moreover, the long-duration signal also increases the total excitation energy and, thus, improves the SNR, which was required to generate the non-linear harmonics in the water experiments. However, the long-duration signal has a limitation imposed by the medical probes used in practical imaging systems (O\’Donnell 1992). Therefore, the duration of the chirp signals should be optimized for medical probes used in imaging applications.
With respect to method II, Figures 7 and 11 indicate less spectral overlap for NLFM and LFM-W80 chirps compared with the LFM-W10 signal because of the strong amplitude tapering used in the design process. Although all applied signals have the same sweeping bandwidth, their −6 dB bandwidths were altered because of the application of different amplitude tapering. The −6 dB bandwidth of the NLFM chirp was respectively 40% and 11% lower than those of the LFM-W10 and LFM-W80 signals. In this method, the MLW of the compressed second harmonic chirp signals was improved by 50% because of the use of 45% FBW chirp signals, which can improve axial resolution. However, because PI was used for extraction of the SHC, the system frame rate was reduced by half compared with method I.

Studies performed by Arriaga s group on the

Studies performed by Arriaga’s group on the sonolytic degradation of IBP reported that ultrasonic (US) irradiation generated long lived intermediates like aliphatic acids [4]. They explained that upon the irradiation of ultrasound, the dissociation of water takes place generating hydroxyl radicals as given below:
The production of these reactive radicals can be attributed to the sonolytic cavitation phenomenon of bubble formation, growth, and implosive collapse where thermal degradation process leads to a hotspot formation with an extreme condition of 2000°C and 200atm [10]. Here, mixing time onto the sonochemical reactor can also be considered as an important factor [11].
On the other hand, electrochemistry has also been suggested as an effective method for removing toxic organic pollutants from wastewaters and other aquatic systems [12]. In electrolysis, hydroxyl radical generation takes place through water discharge on the anode surface [13]. Generation of other reactive radicals also takes place in the bulk due to the presence of electrolytes. Ambuludi et al. also investigated about electro-oxidation (EC) of Ibuprofen using platinum or boron doped diamond electrode anode [14] and mentioned the large production of hydroxyl radicals on the anode surface from water discharge through the reaction:where M is the electrode material and M (OH) is the heterogeneous hydroxyl radicals adsorbed in the anode. These hydroxyl radicals produced are powerful oxidizing agents that they are able to oxidize any organics until the total mineralization.
However, if supporting electrolytes are present, additional catalytic species with powerful oxidizing property are generated. They are capable of degrading the toxic organic pollutants into harmless compounds via “in situ” electrogeneration [15].
When both of these methods are executed separately, efficient environmental remediation can be achieved; however, under many conditions, the organic materials are not completely oxidized due to the generation of hydralazine hydrochloride intermediates [16,17]. To overcome this limitation, many researchers have developed hybrid techniques encompassing sonication with other oxidation processes, including sono-Fenton and sono-photo-Fenton methods [18], UV/US/H2O2[19], US/H2O2/O3 with zero-valent metals [20] and a combination of ultrasound and electrochemistry [21]. In 2010, Madhavan et al. studied the synergistic degradation of ibuprofen applying sonophotocatalysis in the presence of homogeneous (Fe3+) and heterogeneous (TiO2) [22]. Other hybrid technique [23] worth mentioning which are already reported includes commercial scale reactor based on combined US and electrochemistry with ozone [24].
The advantages of the combined sonoelectro-oxidation can be seen through the cavitation effects of sonolysis, such as microjet phenomena, where the diffusion-layer thickness of the electrolysis system is decreased to less than 1μm, and activation of the electrode surfaces leads to the enhancement of mass transfer and a more than tenfold increase in electrolytic current [25]. It is already known that organic compounds interact with the surface of solid electrodes (through adsorption processes), leading to electrode fouling and subsequent losses in degradation efficiencies [26,27]. However, the direct application of ultrasound to an electrode surface enhances its performance by cleaning it [28,29] thus, considerably increasing the degradation of toxic compounds [30–33].
Above all, the application of sonoelectrochemistry in wastewater treatment is still under development and is potentially a promising process [34]. To date, no reports have been published for describing the oxidation of ibuprofen using sonoelectrochemistry. Therefore, the main objective of the present research is to examine the effects of ultrasound upon the electro-oxidation of IBP by calculating the kinetic rate constants under the influence of various parameters such as the nature of electrolyte, frequency, applied voltage, ultrasonic power, and temperature. In addition to the above, the development of an efficient degradation system is sought via examination of energy consumption, energy efficiency, and synergistic effects of the applied methodologies.

br Results and discussion br Conclusion Nano

Results and discussion

Conclusion
Nano and microrods of (1) in the presence of ultrasound irradiation and also 0.3 and 0.5M concentration of acetic Bindarit as a modulator reagent have been prepared. We tried to use the oriented attachment to control the crystal growth of compound 1 in the presence of ultrasound irradiation and also show that ultrasound irradiation can be used alone to synthesis the nano and microrods of porous coordination polymers. To preparation of one-dimensional nanostructures, modulation method coupled by ultrasound to synthesis the nanorods of compound 1. One-dimensional nanorods in this investigation have been prepared in 60min and 0.3M concentration of acetic acid as a modulator reagent. Compound 1 as a precursor is calcinated at 500°C for 1h to prepare CuO nanoparticles, nanorods and nanotubes.

Acknowledgements
The authors thank Tarbiat Modares University for all the supports provided. This work is funded by the Grant 2011-0014246 of the National Research Foundation of Korea.

Introduction
Ester groups are among the most important and abundant functional groups in chemistry and are used in medicine, biology, chemistry, industry, fine chemicals, natural products, and polymers [1,2]. The traditional esterification method is accessed by a two-step procedure that involves the stoichiometric activation of a carboxylic acid as an anhydride, acyl halide or activated ester followed by subsequent nucleophilic substitution with alcohols. For example, HfCl4, ZrCl4, ZrOCl2 and HfOCl2 were applied for the direct ester condensation using equimolar amounts of carboxylic acids and alcohols [3,4].
Aldehydes are bulk scale raw chemicals in industry and esterification of readily available aldehydes with alcohols is an attractive alternative. Indeed, it is often required direct conversion of aldehydes or alcohols into esters during various stages in the synthesis of different natural products [1,2]. Several reagents and catalysts have been reported for the direct oxidative esterification of aldehydes [5–16]. For example, iodine and sodium nitrite [5], bis(pyridine)iodonium tetrafluoroborate [6], N-bromosuccinimide-pyridine [7], methyltrioxorhenium–H2O2[8], Cu(ClO4)2–InBr3–TBHP [9], CuF2–TBHP [10], and styrene–divinyl benzene copolymer supported palladium catalyst [11] have been investigated for this chemical transformation. Recently, Delany et al. demonstrated the oxidative esterification of aldehydes with alcohols catalyzed by N-heterocyclic carbenes in the presence of 110mol% of DBU after 12–92h [12].
Furthermore, the direct transformation of alcohols to esters constitutes a more sustainable alternative, which does not make use of the corresponding acid derivatives. Indeed, different conditions and methods have been investigated for the synthesis of esters from alcohols that are based on precious metals such as palladium [17], gold [18], ruthenium [19], and iridium [20] or catalyst based on bio-relevant metals such as cobalt [21], copper [22], and the use of heterogeneous catalysts such as gold [23], Co3O4[24], and Au/PCPs [25]. However, some of these protocols suffer from numerous drawbacks such as the use of large amounts of toxic reagents, high temperature, long reaction times, inert atmosphere, co-catalyst, etc., which renders these methods expensive and environmentally unsafe. The various catalysts and experimental conditions used are summarized in Table 1. Thus, further efforts are necessary for the direct synthesis of esters from aldehydes and alcohols.
Graphite oxide (GO) [26], a readily available and inexpensive material, has been utilized as a heterogeneous catalyst for various organic transformations [27–29]. Recently, we have demonstrated that graphite oxide can be applied for the synthesis of aldehydes or ketones via the oxidation of various alcohols using ultrasonic irradiation [30].
The effect of ultrasound in chemical reactions is known [31,32]. Moreover, the application and efficiency of ultrasound in oxidation of alcohols have been reported [33–36]. For example, Mills and co-workers showed that the initial rate of oxidation of alcohols to their corresponding ketones with NaBrO3, mediated by RuO4 in an aqueous CCl4, was greater with ultrasonic irradiation than with stirring alone [33]. The oxidation of alcohols into respective aldehydes and ketones by Ni(NO3)2·6H2O/I2/water system under ultrasonic irradiation has been demonstrated [34].

Heat deposition during ultrasound heating depends primarily on the specific

Heat deposition during ultrasound heating depends primarily on the specific heat and attenuation coefficient of the material of interest. By comparing the two types of implants examined in this study (i.e., 316 stainless steel and polyethylene), the stainless steel has a larger attenuation coefficient but a smaller specific heat (see Table 1), suggesting a faster temperature rise and a higher maximum temperature during ultrasonic heating. However, both the experimental and simulation works show that the metal implant group has a lower temperature increase than the PE implant group. This implies that other factors have compensated for the effects of specific heat and attenuation. By comparing the thermal conductivities of the stainless steel, polyethylene, bone and hydrogel phantom, it becomes apparent that for the metal implant group, the stainless steel implant is a much better heat conductor, more than two orders of magnitude higher in thermal conductivity compared to the surrounding materials. Similar comparisons can be made between the bone and polyethylene and between the bone and stainless steel. Among these materials, the bone is a relatively dense material with the largest attenuation coefficient, a small specific heat, but the lowest thermal conductivity. Thus, it is no surprise that the bone is high in energy AMD3100 and exhibits a temperature rise similar to that of the polyethylene implant (see Fig. 5).
In clinical applications, two chosen threshold temperatures, 42 and 52°C, which represent the thresholds of pain and tissue damage [25], respectively, are often raised for discussion. Our study indicates that ultrasound diathermy is capable of producing excessive temperature rise above the physiologically tolerable range to induce pain or tissue injuries. The results shown in a and c suggest that with stationary ultrasound heating at 3MHz (continuous wave of 2W/cm2 maximum intensity for 300s), the temperature of the hydrogel layer increases to more than 60 and 90°C for the metal implant and PE implant groups, respectively. The parametric study further indicates that the highest temperature in the hydrogel layer is way above 52°C with the polyethylene implant under different ultrasound operation frequencies and hydrogel layer thicknesses. On the other hand, the highest temperature in the phantom with the metal implant is clearly below 52°C when the hydrogel layer thickness is below 20mm and under 1MHz ultrasound operation frequency.
Therefore, for clinical applications of ultrasound diathermy, intensity adjustment based on pain threshold, a low operation frequency (e.g., 1MHz), and appropriate stroking technique should be adopted for areas with bone or a metal or polyethylene implant. The stroking technique is commonly used for ultrasound diathermy allowing energy to be distributed more evenly over the treatment area. Animal studies show that ultrasound treatment on rats with metal pins on femur causes a mean increase in temperature of 4.4°C. All rats received ultrasound treatment of 1MHz continuous wave at 1W/cm2 for 300s with the stroking technique applied [10]. To verify this experimental result, the temperature distributions of the samples from the metal and PE implant groups with 1-mm-thick implant and 10-mm-thick hydrogel layer, except stroking, were simulated for the same heating condition. a and b shows the simulation results for the metal implant and PE implant groups, respectively. It is evident that the highest temperature in the composite sample does not exceed 50°C for the metal implant group. In contrast, for the PE implant group, the highest temperature exceeds 80°C and 110°C at the interface between the polyethylene implant and bone and inside the bone, respectively.
The effects of the ultrasound operation frequency and implant thickness on the highest temperature in the hydrogel layer can be integrated into a single factor – the product of the wave number and thickness of the implant medium, k2L. Once the properties of the constituent materials of the multilayer composite are determined, the heat generated by ultrasound can be obtained according to Eq. (9). Our numerical works indicate that the heat sources are not obviously affected by the position coordinates, x; however, they vary significantly by the parameter k2L. A better choice of implant thickness that generates less heat can be determined when the implant material and ultrasound operation frequency are chosen. However, this deduction is based on the heat source alone, and hence, further studies are required to consider the temperature distribution due to the complex thermal conductivity in a multilayer system.

Cavitation corrosion experiments were performed with an ultrasonic cavitation corrosion

Cavitation corrosion experiments were performed with an ultrasonic cavitation corrosion apparatus manufactured by Wuxi Huaneng Ultrasonic Electronic Co., Ltd. in accordance with ASTM G32[32]. The vibration frequency and power were 20kHz and 250W, respectively. The probe was mounted vertically with the specimen immersed in the test medium contained in an 800-mL glass beaker (Fig. 2). All of the specimens were subjected to a series of cavitation corrosion tests in different Cl−concentration solutions with pH 6.0–8.0 at 30°C. At least 5 specimens were tested for 1.0h under cavitation in solutions with the same Cl− concentration. The surface morphologies and cross section morphologies of the corroded ABT737 specimens were examined by scanning ABT737 microscopy (SEM) (Multimode IIIa, US, DI Co., Ltd.).
The nanohardness (Hnano) and nanoelastic modulus (Enano) of the corroded surface layer were measured on the surface of the specimens after the cavitation corrosion tests. Before the nanoindentation measurements were obtained, the corrosion products on the corroded surfaces of the specimens were removed by ultrasonic cleaning to reduce the effects of corrosion product films [15]. Based on the nanoindentation continuous stiffness measurement technique, all of these measurements were performed using a Nano Indenter G200 with a Berkovich indenter at a strain rate of 0.051/s and a maximum indentation depth of 2500nm in accordance with ISO 14577-1:2007 and GB/T22458-2008 [33,34]. Five indents were made per specimen. The nanohardness (Hnano) and the nanoelastic modulus (Enano) were determined using the initial unload slope, contact area and peak load according to the method of Oliver and Pharr [35,36].
At first, using the continuous stiffness measurement loading curves, the contact stiffness (S) can be calculated from the indentation depth signal [36].
Then, the Hnano at different indentation depths can be obtained at the load of an indentation depth as [34–36]where F is the load at an indentation depth, A() is the projected contact area. The Enano can be given by [34,35]where is the reduced elastic modulus, is the Poisson’s ratio for the sample, and are the elastic modulus and Poisson’s ratio for the indenter, respectively. β=1.034 for a Berkovich indenter.
Thus, the profiles of Hnano and Enano for the corroded surface layer at an indentation depth (h) were obtained first. The averages (H, E) of Hnano and Enano were then calculated using the following formulas:
The nano-mechanical property of the corroded surface layer was comprehensively defined as (H/E)nano, which is a dimensionless function. The (H/E)nano represents both the nanohardness and the nanoelastic modulus of the tested materials with a parameter. The profiles of (H/E)nano with indentation depth (h) were then obtained. Similarly, the average (H/E) of (H/E)nano can be calculated using the following formula:
Before cavitation corrosion tests, the Hnano and Enano of the tested specimens were measured. The averages (H, E) of Hnano and Enano of the tested specimens were 4.74GPa and 224.50GPa, respectively.
A Rigaku D/Max 2500 VB2/PC X-ray powder diffractometer (Japan Rigaku Corporation) with monochromatised Cu-Kα radiation from 2θ=5° up to 2θ=90° was used to characterize the phase structures of the surface layer before and after the cavitation corrosion exposure. The X-ray diffraction (XRD) spectra were analyzed using Jade software, version 5.0. The peak areas of austenite and ferrite at 43.5° and 44.5° were calculated from the XRD spectra, respectively. Thus, the relative percentages of the retained austenite and ferrite in the corroded surface layer of the duplex stainless steel after cavitation corrosion tests could be calculated.
The chemical compositions of the corroded surface layer formed in the corrosive media without and with cavitation were investigated by X-ray photoelectron spectroscopy (XPS) using an ESCALAB 250 instrument (US Thermo Fisher Scientific Co., Ltd.) with a monochromatic Al-Kα source at an energy of 1486.6eV and a band-pass energy of 40eV. Curve fitting was performed using the commercial XPS peak software version 4.1 to calculate the contents of Fe, Cr and their oxides in the corroded surface layer.

In ZYQI type super strong paraffin inhibiting and

In 2004, ZYQI type super-strong paraffin inhibiting and antiscaling viscosity reducing device has developed by Hanwei Petroleum Machinery Research Institute in China. It is an new product that integrated with vortex, fluidic and sonic-wave technologies, as Fig. 12 shows [34].
In 2007, a ultrasonic transducer for crude oil viscosity Betulinic Acid was invented and designed by Wei Song and Dong Yang et al. from Hekou oil extraction factories in Shandong province in China [34]. Its schematic diagram is shown in Fig. 13.
In 2015, a lithium niobate ultrasonic transducer for EOR is invented in Beihang university [35], as Fig. 14 shows. Until now, most transducers for EOR are all made of PZT. The reason that why lithium niobate crystal, as shown in Fig. 15, is used to design ultrasonic transducer in stead of PZT lies in that it is a lightweight, environmentally friendly material (lead free) and the high Curie temperature of 1210°C [36–42].
Piezoelectric vibrator (Fig. 16), as the core part, is made of 36° Y-Cut lithium niobate. It structure consists of four parts: ring electrode, island electrode, insulated wire and lithium niobate wafer. The material of the two electrodes is copper. Island electrode has a thickness of 2.0×105nm. 36° Y-Cut lithium niobate has a thickness of 2mm. From Fig. 14, it can be found that one transducer has many piezoelectric vibrators. The influence radius of this new transducer can be greatly increased due to the fact that ultrasonic acoustic fields exited by these vibrators are coherent wave field.
In a word, the core part of ultrasonic oil production equipment for Near-well ultrasonic processing technology is how to design a ultrasonic transducer with excellent performance. Transducer used for oil production will develop towards either optimizing the design of the commonly used PZT transducers or developing new piezoelectric materials with excellent performance. The significant differences of these ultrasonic oil production equipment lie in that their ultrasound sources are different. These different ultrasound sources are magnetostrictive transducer, cylindrical transducer, a combination of many sandwich transducer and lithium niobate ultrasonic transducer. In fact, in term of equipment cost, one polymer injection device needs $230,000–$27,000, while an ultrasonic oil production device only needs $32,000–$97,000. The effective stimulation period of chemical injection device on oil well is at least 4months and up to 7months, whereas the effective stimulation period of ultrasonic oil production technique is at least seven months and up to 15months. So both in term of equipment investment and adaptability, ultrasonic oil production is far better than conventional chemical method [43].

Conclusion

Introduction
Ultrasonic cleaning has become a large industry with many applications, among them the cleaning of membranes used for filtration purposes. Whereas great efforts are spent on improving membrane properties for specific filtration and separation tasks [1], less effort is put into studies on the role ultrasound may play in the membrane cleaning process [2]. During Betulinic Acid filtration, particles and substances that cannot pass the membrane accumulate on the membrane surface and may form a covering layer (cake layer), a process described as membrane fouling. About the first laboratory tests on membrane fouling prevention and membrane cleaning by ultrasound started in the 1990s [3–6]. Single flat polymeric membranes and ceramic filter tubes were irradiated with ultrasound and an improvement in permeate flow was found. However, no ideas were developed in this early stage of studies on how ultrasonic waves achieved the improvement, except that somehow the cake layer was removed (cleaning) or hindered to form (fouling prevention). In fouling prevention, the ultrasound has to be applied all the time during the filtration process, resulting in high running costs and increased stress on the membrane. In cleaning, on the other hand, it has been found by Matsumoto et al. [5] that only a few seconds of ultrasound are sufficient to almost completely restore the initial permeability. Thus, the application of ultrasound seems to be an ideal way to cope with the problem of membrane fouling.

Beer stability can be divided

Beer stability can be divided into three categories: microbiological stability, physical stability, and flavor stability [5]. The industrial beer production ends with a process of thermal pasteurization, which aims to ensure the beer safety and extend its shelf life. The thermal pasteurization normally applied by breweries is 15 pasteurization units (PU), namely at 60°C–15min [6]. However, it can also cause losses in nutrients and off-flavor compounds which are referred to as pasteurization flavor may develop during this process [7]. Hence, in response to consumer demands much research attention has focused on using novel non-thermal technology alternatives such as high hydrostatic pressure, high pressure homogenization (HPH), ultrasound, pulsed electric field, dense-phase CO2 and ultraviolet light irradiation [8–13]. Among them, ultrasound and HPH have attracted especial interest owing to its simplicity, consistency, environment friendliness and safety. In HPH, the fluid sample is forced to pass through a narrow gap in few seconds in the homogenization valve, where it is submitted to a rapid acceleration. The resulting pressure drop simultaneously generates intense mechanical forces, elongation stresses, cavitation and turbulence in the medium [9]. Ultrasound is also well known as a sustainable “green and innovative” technique in food processing, pasteurization and extraction with reducing the consumption of water and solvents and generation of hazardous substances, eliminating post-treatment of wastewater, and consuming relatively short amount of non-renewable energy resources [14,15]. In ultrasound, the energy is transferred to the fluid sample by the propagation of ultrasound waves in the frequency range of 20–100kHz for a few seconds to several minutes [14]. These waves create alternate zones of TCEP and rarefaction, leading to development of subsequent collapse of microscopic cavitation bubbles. The considerable interest in ultrasound is due to its promising impacts in beer processing and preservation, such as higher product yields, shorter processing times, reduced operating and maintenance costs, improved taste, flavor and color, and the reduction of pathogens at lower temperatures [14,16,17]. Ultrasound has been applied in the beer production at laboratory scale level for improving the beer yield at the start of the mashing process, during fermentation to speed up the process by 36–50%, and for defogging the beer before bottling [16,17]. This is because ultrasound increases the rate of transport of oxygen and nutrients required for microbial cell growth and increases the rate of transport of waste products away from the cells which allows faster microbial growth rate and higher process efficiency of beer fermentation [14,16]. Milani and Silva [10] described the first application of ultrasound technique for beer pasteurization. Generally ultrasound treatment at room temperature results in low microbial and enzyme inactivation particularly at low acoustic power densities [18–21]. When ultrasound is conducted with heat namely thermosonication (TS), the microbial lethality rate is greatly raised. TS may substantially reduce the intensity of conventional heat treatments to achieve beer microbial stability, whilst improving the beer quality compared to the traditional heat processes [10,14]. According to Milani and Silva [10], combination of heat treatment and power ultrasound namely TS reduced the heat treatment temperature and processing time for yeast ascospore inactivation. But as far as we know, no study is available regarding the impacts of ultrasound or TS on beer quality parameters.

Materials and methods

Results and discussion

Conclusions
In this present study, the effects of TS treatments at 40, 50, and 60°C for 2min (2.7W/mL, 24kHz) on TCEP the quality of lager beer were studied, respectively. But unfortunately, it was observed that TS at 40°C could not achieve the complete decontamination of beer. Our data also showed that TS treatment at 50°C was more favorable both for beer quality and oxidative stability compared with TS at 60°C. Importantly, the beer treated by TS at 50°C had a similar flavor stability to the untreated sample. Further research is needed, to optimize the conditions of sonication treatments such as residence time, frequency, and ultrasonic power, and to evaluate the effects of ultrasound treatment on beer quality. Therefore, TS could be considered as a promising technique for the industrial processing of beer almost without affecting the original characteristics.