Archives
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Because of the lack of sequence current knowledge on the
2020-11-17
Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge
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The Penicillium strain used in this work
2020-11-17
The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a
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A decrease in heme levels enables the phosphorylation of eIF
2020-11-16
A decrease in heme levels enables the phosphorylation of eIF2α by HRI and thereby inhibition of eIF2α activity. Indeed, the relatively small change in cytosolic heme levels in SZ IGF-1, human recombinant mg showed downstream functional consequences manifested by almost 50% elevation in the phosphor
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br Materials and methods br Results br Discussion
2020-11-16
Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa
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The UPP broadly involves proteolysis in biochemical processe
2020-11-16
The UPP broadly involves proteolysis in biochemical processes and is a potential target for cancer therapy. The UPP degrades unfolding or damaged proteins by an ATP-dependent mechanism (Ciechanover, Elias, Heller, Ferber, & Hershko, 1980). It also plays an important role in nitric oxide inhibitor re
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The larger eukaryotic ligases such as LigI
2020-11-16
The larger eukaryotic ligases, such as LigI and LigIV, also possess an additional N-terminal DNA-binding domain (DBD) that is required for efficient ligation (Fig. 1c) and enables these ligases to encircle DNA [17]. An equivalent helix–hairpin–helix domain is also present in the bacterial NAD-depend
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Methylation of histone tails is important in regulating
2020-11-16
Methylation of histone tails is important in regulating Doramapimod structure and transcription. Methylation occurs at arginine and at mono-, di- or tri-methylated lysine residues. The reversibility of histone methylation was recently revealed by the identification of two histone demethylases, LSD1
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The use of SP in IPTp may not be the
2020-11-16
The use of SP in IPTp may not be the only driver of parasite polymorphisms in this population, because Senegal has used sulfadoxine and/or pyrimethamine in the national antimalarial treatment plan for many years, and furthermore these drugs are still being used in antibacterial combination therapy.
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The first example of a
2020-11-16
The first example of a broadly-acting antiviral drug is ribavirin, a nucleoside analogue that was proposed to act directly at the level of the viral polymerase, although an indirect effect via inhibition of the host-cell IMP dehydrogenase and depletion of the GTP pool seems more plausible [9]. Anoth
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br Introduction Noncanonical nucleoside triphosphates
2020-11-16
Introduction Noncanonical nucleoside triphosphates (NTPs; such as deoxyinosine triphosphate (dITP), deoxyxanthosine triphosphate (dXTP), 8-oxo-deoxyguanosine triphosphate, and 2-oxo-deoxyadenosine triphosphate are produced from oxidation, deamination, or other modifications of canonical nucleotid
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Keratin K has been identified as the first intermediate
2020-11-16
Keratin 8 (K8) has been identified as the first intermediate filament expressed during development in amphibians and mammals. In zebrafish, a type II cytokeratin 8 (zf-K8) cDNA has been cloned. zf-K8 gene was maternally inherited and expressed in all surface cells throughout the embryonic stages old
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A previous report showed that the transfer of the CSF
2020-11-16
A previous report showed that the transfer of the CSF1 gene into tumor IPA-3 induced TAM infiltration into syngeneic BALB/c mice. High expressions of CSF-1 and CSF-1R in tumor and stromal cells and a high TAM density are known to be correlated with poor prognoses in many cancer types. CSF-1 promotes
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Nevertheless two problems exist in BGCFC in practice The
2020-11-16
Nevertheless, two problems exist in BGCFC in practice. The first one is that time complexity of the ID assignment algorithm presented in Section 3.1 is O(N!), which means a factorial time complexity. Because it obtains the consecutive IDs by enumerating all permutations of ID 0 to N−1, the total num
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Sensory gating describes a filter mechanism protecting the c
2020-11-16
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits HA-100 hydrochloride mg to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2
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BAMB-4 Organ fibrosis is thought to
2020-11-16
Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial BAMB-4 induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the profibrot