• AP20187: Advancing Conditional Gene Therapy via Precision...

  2025-10-26

  Explore AP20187, a synthetic cell-permeable dimerizer, as a pioneering conditional gene therapy activator. This article delves into its molecular mechanisms, unique research applications, and cross-talk with emerging signaling pathways—offering insights beyond standard usage.

• ABT-263 (Navitoclax): Precision Bcl-2 Inhibition in Apopt...

  2025-10-25

  Leverage ABT-263 (Navitoclax) to dissect mitochondrial apoptosis, optimize caspase-dependent assays, and translate novel RNA Pol II-linked cell death mechanisms into actionable cancer biology workflows. This guide details applied protocols, advanced use-cases, and troubleshooting strategies, empowering researchers to maximize the impact of this oral Bcl-2 family inhibitor.

• c-Myc tag Peptide: Advanced Mechanisms in Transcription F...

  2025-10-24

  Explore the unique mechanistic insights of the c-Myc tag Peptide in transcription factor regulation and cancer biology. This in-depth article reveals advanced applications of the synthetic c-Myc peptide for immunoassays, building on recent autophagy and proto-oncogene research.

• 10058-F4: A Next-Gen Small-Molecule c-Myc Inhibitor in Ap...

  2025-10-23

  10058-F4 stands out as a cell-permeable c-Myc-Max dimerization inhibitor, empowering researchers to dissect oncogenic transcription and mitochondrial apoptosis with high specificity. Its proven efficacy in acute myeloid leukemia and prostate cancer xenograft models, combined with actionable workflow optimizations, makes it an essential tool for advanced apoptosis assays and telomerase regulation studies.

• 10058-F4: Small-Molecule c-Myc Inhibitor for Apoptosis As...

  2025-10-22

  10058-F4 redefines precision in apoptosis and cancer pathway research as a cell-permeable c-Myc-Max dimerization inhibitor. Its unique mechanism—disrupting c-Myc/Max heterodimers—enables advanced functional studies in acute myeloid leukemia, prostate cancer, and telomerase regulation. Unlock robust, reproducible workflows and actionable troubleshooting strategies for your next-generation oncology experiments.

• 10058-F4: Unlocking c-Myc-Max Dimerization Inhibition for...

  2025-10-21

  Explore how the small-molecule c-Myc-Max dimerization inhibitor 10058-F4 advances apoptosis assay development and telomerase regulation research. This article uniquely bridges mitochondrial apoptosis, TERT expression, and stem cell biology for translational oncology.

• 10058-F4: Advancing c-Myc-Max Inhibition for Targeted Apo...

  2025-10-20

  Explore how 10058-F4, a cell-permeable c-Myc-Max dimerization inhibitor, uniquely enables targeted apoptosis assays and advanced research into stem cell telomerase regulation. This article delves deeper into mechanistic crosstalk between oncogenic pathways and DNA repair than previous reviews.

• 10058-F4: Advanced c-Myc-Max Dimerization Inhibitor for A...

  2025-10-19

  10058-F4 is a potent, cell-permeable c-Myc-Max dimerization inhibitor, enabling targeted disruption of oncogenic transcriptional programs and mitochondrial apoptosis. This guide details optimized workflows, advanced applications in leukemia and prostate cancer models, and troubleshooting strategies for maximizing research impact.

• Beyond the Bench: Harnessing c-Myc Tag Peptide for Next-G...

  2025-10-18

  This thought-leadership article bridges mechanistic depth and actionable strategy for translational researchers. It explores how the c-Myc tag Peptide (A6003) is revolutionizing the dissection of transcription factor dynamics, immunoassays, and proto-oncogene c-Myc biology—expanding relevance to cancer research and immune signaling. By integrating evidence from cutting-edge autophagy research and benchmarking innovations, this resource offers a visionary pathway for leveraging synthetic c-Myc peptides in high-impact translational workflows.

• Chloroquine: Autophagy Inhibitor for Advanced Research Wo...

  2025-10-17

  Chloroquine, a dual autophagy and Toll-like receptor inhibitor, empowers malaria and rheumatoid arthritis research with precision pathway modulation. Discover optimized protocols, troubleshooting strategies, and future-facing applications that set this anti-inflammatory agent apart as a pivotal scientific tool.

• Diclofenac in Translational Inflammation Research: Mechan...

  2025-10-16

  Explore the multifaceted role of Diclofenac, a non-selective COX inhibitor, in human-relevant inflammation and pharmacokinetic research. This in-depth article uniquely analyzes Diclofenac's utility in translational models, bridging molecular action, advanced organoid assays, and the latest stem cell-derived methodologies.

• It has been known that LOX is

  2023-07-06

  

  It has been known that 5-LOX is the rate-limiting enzyme for the products of LTs, and LTs actively participate in the activation of neutrophils [10]. In our study, we determined whether 5-LOX was upregulated in pancreatic tissues during ANP. Moreover, we investigated whether the inhibition of expres

• br Results and discussion br Conclusions

  2023-07-06

  

  Results and discussion Conclusions In this report we present the synthesis, structure determination, and the in vitro and in vivo evaluation of a series of new quinone analogues aiming to find novel lead structures for the development of 5-LO inhibitors. Our findings support that also the hydr

• The identification of novel kinase inhibitor scaffolds

  2023-07-05

  

  The identification of novel kinase inhibitor scaffolds is highly desirable in order to develop selective kinase inhibitors. Small-molecule inhibitors of Interleukin-2-inducible T-cell kinase (Itk) that are based on the 3-aminopyridin-2-one fragment 1 have been reported. Despite derivatisation of 1 y

• The phylogenetic relationship demonstrates that both bovine

  2023-07-05

  

  The phylogenetic relationship demonstrates that both bovine and porcine 12/15-LO is more related to the human enzyme than the rabbit enzyme, despite the fact that the rabbit reticulocyte enzyme is a 15-lipoxygenase. The rabbit is one single species that expresses a 12/15 LO with 15-LO activity while

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